论文部分内容阅读
为进一步考核用ＳＡ１４－１４－２株生产的流行性乙型脑炎（乙脑）减毒活疫苗接种儿童后的血清学效果，在湖北省乙脑流行区，对某山区小学从未接种过乙脑疫苗的９７名７～１３岁健康小学生接种该疫苗。免疫前和免疫后１个月采血检测乙脑中和抗体，结果：免前中和抗体阳性者８６人（８８．６６％），中和指数ＧＭＴ为１：６９５．３２，免疫１针后１个月，抗体阳性率达到１００％，中和指数ＧＭＴ为１：２７７８．２７；免疫前抗体阴性的１１名儿童，免疫后１个月全部阳转；免疫前中和指数≥１１０００者５４人（占５５．６７％），免疫后１个月增至８１人（８３．５１％）；６０．８２％的儿童免疫后１个月中和抗体滴度较免疫前增长≥２倍。这证明该疫苗免疫效果良好
In order to further evaluate the serological effects of live attenuated JE vaccines vaccinated with SA14-14-2 strain in children exposed to JE epidemic in Hubei Province, Ninety-seven healthy primary schoolchildren aged 7-13 years were given the vaccine. Before immunization and 1 month after immunization, blood samples were collected to detect JE neutralizing antibody. Results: There were 86 (88.66%) patients with positive preimmune antibody, neutralization index GMT was 1: 695.32, 1 after immunization Month, the positive rate of antibody reached 100%, the neutralization index GMT was 1: 2778.27; 11 immunized before antibody negative children, all positive one month after immunization; Immunization before neutralization index ≥ 11000 54 people ( Accounting for 55.67%), 81 (83.51%) increased one month after immunization; and the antibody titers of neutralizing antibody in one month after immunization increased by 2 times than that before immunization. This proves that the vaccine has good immunization effect