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对某厂枪弹制造作业人员肝癌死亡进行了回顾性队列研究。观察组１９２８人，观察２７７８２人年，对照组６７６人，观察９７０１人年，失访率均低于５％。观察期从１９８１年１月１日至１９９５年１２月３１日。以哈市一般人群为参比标准时，观察组男性肝癌标化死亡比（ＳＭＲ）为１７９（９５％ＣＩ１１３～２６８）。与对照组比，年龄分层相对危险度（ＲＲＴ）为１５４；观察组中熔铜工男性ＳＭＲ４４８（９５％ＣＩ１６４～９７５），ＲＲＴ为４５０（Ｐ＜００１）。观察组饮酒男性ＳＭＲ是２３９（９５％ＣＩ１３１～４０２），对照组不饮酒男性１例肝癌死亡。调查结果提示：观察组熔铜工接触的职业有害因素与饮酒可能对该队列肝癌死亡超量有协同作用。
A retrospective cohort study was conducted on the death of liver cancer from a bullet-maker at a factory. 1928 in observation group, 27782 in observation year, 676 in control group and 9701 in observation year. The loss rate of follow-up was less than 5%. Observation period from January 1, 1981 to December 31, 1995. When the general population in Harbin was taken as the reference standard, the standardized mortality ratio (SMR) of male patients in observation group was 1.79 (95% CI 1.13-2.68). Compared with the control group, the relative risk of age stratification (RRT) was 154. In the observation group, SMM4.48 (95% CI 1.64 to 975) and RRT was 4.50 (P0.01) 01). In the observation group, the SMR of drinking men was 239 (95% CI 1.31 ~ 402), while in the control group, 1 case of liver cancer died from drinking non-drinking men. The survey results suggest that the occupational harmful factors and alcohol consumption in the observation group may be synergistic to the death of liver cancer in this cohort.