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目的分析脑动脉狭窄支架置入后支架内再狭窄与同型半胱氨酸的关系。方法将55例成功接受支架置入治疗的脑动脉狭窄患者,根据同型半胱氨酸水平分组:正常组(n=30)、升高组(n=25)。支架置入后患者常规行脑血管造影随访,以原靶病变管腔直径狭窄≥50%为支架内再狭窄,分析同型半胱氨酸与脑动脉支架术后再狭窄的关系。结果 55例患者中,6例发生支架内再狭窄,占11%,其中正常组中有2例发生再狭窄,升高组中有4例发生再狭窄。升高组中支架内再狭窄比率明显高于正常组(P<0.05)。结论高同型半胱氨酸血症加大脑动脉支架置入后再狭窄的风险,对于高同型半胱氨酸血症的治疗或可降低支架再狭窄的几率。
Objective To analyze the relationship between in-stent restenosis and homocysteine after stent implantation in cerebral artery stenosis. Methods Fifty-five patients with cerebral artery stenosis who underwent stent implantation were divided into two groups according to homocysteine level: normal group (n = 30) and elevated group (n = 25). After stent implantation, patients underwent routine cerebral angiography follow-up. The original target lesion lumen diameter stenosis ≥ 50% for in-stent restenosis, analysis of homocysteine and cerebral artery stent restenosis after the relationship. Results Of the 55 patients, 6 had in-stent restenosis (11%), of whom 2 had restenosis in the normal group and 4 had restenosis in the elevated group. The rate of in-stent restenosis in the elevated group was significantly higher than that in the normal group (P <0.05). Conclusions Hyperhomocysteinemia increases the risk of restenosis after cerebral arterial stent placement and may reduce the risk of stent restenosis for the treatment of hyperhomocysteinemia.