人乳头瘤病毒(Human papilloma virus,HPV)属于乳头瘤病毒科的乳头瘤病毒属,为球形无包膜的环状双链DNA病毒,直径为52~55nm。依据不同型别HPV与肿瘤发生的危险性高低分为低危险型别和高危险型别HPV,低危险型别HPV包括HPV6、11、42、43、44等型别,常引起外生殖器湿疣等良性病变,包括宫颈上皮内低度病变(CINⅠ);高危险型HPV包括HPV16、18、31、33、35、39、45、51、52、56、58、59、68等型别,与宫颈癌及宫颈上皮内高度病变(CINⅡ/Ⅲ)的发生 Human papilloma virus (HPV) belongs to the genus Papillomavirus of the Papillomavirus family. It is a globular uncoated circular double-stranded DNA virus with a diameter of 52-55 nm. According to different types of HPV and tumor risk level is divided into low-risk type and high-risk type of HPV, low-risk type of HPV, including HPV6, 11,42,43,44 and other types, often cause Genital warts Benign lesions, including cervical intraepithelial lesion (CIN Ⅰ); high-risk HPV including HPV16,18,31,33,35,39,45,51,52,56,58,59,68 and other types, and cervical Cancer and cervical intraepithelial lesions (CIN Ⅱ / Ⅲ)