The nuclear area (A)and nuclear roundness factor (NRF) of epithelial cells of 42 esophageal cancers and 10 normal esophagus’s were measured by morphometry and the results were compared with the extent of the tumor The nuclear area (A)and nuclear roundness factor (NRF) of epithelial cells of 42 esophageal cancers and 10 normal esophagus’s were measured by morphometry and the results were compared with the extent of the tumor