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在我国,对新生隐球菌(Cryptococcus neoformans)已进行了较系统的研究。生态学方面,,由鸽粪分离的环境株具有表型的多态性,包括新生变种的A、D血清型及尿素酶阴性株,而这些多态性菌株均已在临床发现。分子生物学方面,G+Cmol％和核型已被进行分析。,由PFGE分析所得到的有意义的信息是两个变种和5种血清型新生隐球菌株具有明显不同的核型谱。临床方面,研制的一种新的可同时检测酚氧化酶和尿素酶的培养基可用于该菌的临床鉴定。使用一种高渗培养基诱导出于该菌的L-型,提示在感染期间L-型的形成可能与该病的慢性过程与复发有关。已证实氟康唑对治疗新生隐球菌病有良好的效果。进一步应重视联合治疗的可能性,例如使用氟康唑加二性霉素B脂质体。总之在我国对新生隐球菌的系统性研究已经初步开始进行,许多有意义的结果已经得到并且将进一步得到。
In our country, Cryptococcus neoformans has been systematically studied. In terms of ecology, the environmental strains isolated from pigeon fecundity have phenotypic polymorphisms, including the A, D serotypes and urease negative strains of the newborn variety, and these polymorphic strains have been clinically discovered. In molecular biology, G + C mol% and karyotype have been analyzed. , The significant information obtained from the PFGE analysis was that the two variants and the five serotypes of Cryptococcus neoformans had significantly different karyotypes. Clinically, a new medium that can detect both phenoloxidase and urease can be used for the clinical identification of the bacteria. The induction of L-forms from this strain using a hypertonic medium suggests that the formation of L-forms during infection may be related to the chronic course and recurrence of the disease. Fluconazole has been shown to have a good effect in the treatment of cryptococcosis. Further attention should be paid to the possibility of combination therapy, such as the use of fluconazole plus amphotericin B liposomes. In short, systematic research on Cryptococcus neoformans in China has initially begun, and many meaningful results have been obtained and will be further obtained.