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目的：脓毒症常为引起急性肾损伤的原因，但临床中急性肾损伤并发脓毒症的发病情况尚待明确。方法分析住ICU患者中发生AKI者共计424例。据患者诊断AKI患者发生脓毒症的时间进行分层。结果对患者的临床特点、是否需要血液净化、住院时长、在院死亡等进行分析，424例患者中，158例在AKI之前发生脓毒症，109例未发生脓毒症，157例AKI后发生脓毒症，中位时间为4.5天。AKI后发生脓毒症者死亡率明显高于未发生脓毒症者（19.1%vs.10.1%，P<0.05），与未发生脓毒症患者相比，AKI后发生脓毒症者需行血液净化治疗者比例更高、住院时间更长、体液潴留、病情更重、少尿或无尿更严重，血液透析是发生脓毒血症的危险因素。结论脓毒症常发生于AKI患者中，是不良预后的预测因素，死亡率高，住院时间长，应在AKI患者严密监测避免发生脓毒血症。“,”Objective sepsis often related with acute kidney injury,but the incidence of acute kidney injury in clinical sepsis has yet to clear.Methods:total of 424 patients with AKI in ICU were stratified according to the time of diagnosis of AKI.Results:The clinical characteristics of patients,the need for blood purification,length of hospitalization, inhospital death were analyzed in 424 patients,septic after AKI happened in 157 patients.109 patients with AKI were sepsis-free,157 patients of septic happened after AKI with a median time of 4.5 days.Sepsis mortality was significantly higher than those who did not occur(19.1%vs.10.1%,P<0.05),compared with patients without sepsi with longer hospital stays,fluid retention,oliguria, hemodialysis is a risk factor for sepsis.Conclusion:Sepsis often occurs in patients with AKI,are predictors of poor prognosis and high mortality,long hospital stay,AKI patients should be monitored closely to avoid sepsis.