Background Pre-operative chemotherapy has gained widespread interest while treating advanced gastric cancer in eastern countries.However,there is currently no established standard regimen for gastric cancer.The aim of this research was to explore the value of preoperative chemotherapy with a combination of intravenous and intra-arterial intensified chemotherapy in advanced gastric cancer.Methods A total of 56 histologically proven gastric cancer patients,who were considered to be stage Ⅱ or higher with metastatic lymph nodes and with or without distant metastasis (T2-4,N1-3,and M0-1),were treated with a neoadjuvant chemotherapy.Patients received a combination of intravenous 5-Fu (370 mg/m2) and leucovorin (200 mg/m2) on days 1-5,and intra-arterial etoposide (80 mg/m2) and cisplatin (80 mg/m2) on days 6 and 20.After two cycles of preoperative chemotherapy,patients with resectable tumors underwent laparotomy.Results All patients finished two cycles of chemotherapy.The overall response rate was 78.57％ (44 cases),of which 7.14％ (four cases) clinical complete response.Forty-six patients underwent resection,including 21 initially unresectable diseases.R0 resection rate for prechemotherapy resectable and unresectable diseases was 96.15％ (25/26 cases) and 66.67％ (20/30 cases),respectively.Pathological complete response was observed in 8.70％ of patients.Toxicity was moderate and there were no chemotherapy-related deaths.With a median follow-up of 31 months (range 6-76 months),the 5-year survival rate for the whole group and patients with initially resectable tumors were 21.8％ and 42.3％,respectively.The median survival for initially resectable and unresectable patients were 41 months (95％CI,31.006-50.994) and 18 months (95％CI,13.399-22.601; P ＜0.01),respectively.Conclusion Preliminary results proved that the combined intensive chemotherapy was a safe and promising regimen for pre-operative treatment of advanced gastric cancer.