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目的探讨缺氧诱导因子-1α(HIF-1α)在胃癌组织中的表达及其意义。方法选择120例胃癌标本(胃癌组)、68例正常胃黏膜组织(对照组),采用SP法检测两组HIF-1α的表达,并分析HIF-1α的表达与临床病理特征的关系。结果胃癌组HIF-1α阳性表达率为70.83%,对照组不表达,两组比较P<0.01。胃癌组中不同肿瘤分期、分化程度、浸润深度、淋巴结转移间HIF-1α阳性表达率差异均有统计学意义(P均<0.01)。结论 HIF-1α可作为评估胃癌发展、转移及预后的参考指标。
Objective To investigate the expression and significance of hypoxia-inducible factor-1α (HIF-1α) in gastric cancer. Methods 120 cases of gastric cancer (gastric cancer group) and 68 cases of normal gastric mucosa (control group) were selected. The expression of HIF-1α was detected by SP method. The relationship between the expression of HIF-1α and clinicopathological features was analyzed. Results The positive expression rate of HIF-1α in gastric cancer group was 70.83%. No expression was found in the control group. The difference between the two groups was P<0.01. There were significant differences in the positive rate of HIF-1α between different stages of tumor, differentiation, depth of invasion, and lymph node metastasis in gastric cancer group (P<0.01). Conclusion HIF-1α can be used as a reference to evaluate the development, metastasis and prognosis of gastric cancer.