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目的观察静脉注射免疫球蛋白联合纳洛酮治疗病毒性脑炎临床症状缓解快慢和治疗效果。方法选择病毒性脑炎患儿86例,随机分成两组,两组均43例,对照组选用常规治疗,治疗方法为抗感染、脱水降颅压、镇静止惊等综合治疗,治疗组加用静脉注射免疫球蛋白和纳络酮。静脉注射免疫球蛋白用法为:400 mg/(kg.d),连用3～5 d,或1g/(kg.d),连用2 d;纳络酮的用法为:每次0.01 mg/kg,最大剂量为2 mg,2～3 min后可重复使用。观察两组临床症状缓解快慢和治疗情况。结果治疗组与对照组比较,在临床症状改善方面治疗组明显快于对照组(P<0.01),两组疗效比较治疗组较对照组好,差异有统计学意义(P<0.05)。结论治疗组治疗加用静脉注射免疫球蛋白和纳洛酮治疗病毒性脑炎临床症状缓解快,治疗效果较好,安全可靠,且不良反应少。
Objective To observe the clinical effect of intravenous immunoglobulin combined with naloxone in the treatment of viral encephalitis and the treatment effect. Methods Eighty-six children with viral encephalitis were randomly divided into two groups, 43 cases in both groups. The control group was treated by conventional therapy. The treatment was anti-infective, dehydration and intracranial pressure, Intravenous immunoglobulin and naloxone. Intravenous immunoglobulin usage: 400 mg / (kg.d), once every 3 ~ 5 d, or 1g / (kg.d), once every 2 d; Naloxone usage: 0.01 mg / kg each time, The maximum dose of 2 mg, 2 ~ 3 min after repeated use. Observe the clinical symptoms of both groups to alleviate the speed and treatment. Results Compared with the control group, the treatment group was significantly faster than the control group (P <0.01). The curative effect of the two groups was better than that of the control group (P <0.05). Conclusion The treatment group treated with intravenous immunoglobulin and naloxone in the treatment of viral encephalitis clinical symptoms relieved quickly, the treatment effect is good, safe, reliable, and less adverse reactions.