论文部分内容阅读
对单项抗-HBc阳性者接种乙肝疫苗并随访7个月.抗-HBs应答率为61.2％.首次疫苗接种后的无应答者,不对第二、三次接种产生抗-HBs应答。应答者的抗-HBs滴度随接种次数而逐渐升高.抗—HBs阳性者对乙肝疫苗的免疫应答可能是原发反应。从抗—HBc阳性的无应答者血清中检出HBV—DNA和HBsAg,提示无应答者可能处于一种轻微的慢性染感状态.
Hepatitis B vaccine was administered to individual anti-HBc positive patients and followed up for 7 months.The response rate of anti-HBs was 61.2% .Non-responders after the first vaccination did not have anti-HBs response to the second and third inoculations. The anti-HBs titer of the responders gradually increased with the number of inoculations.The immune response to hepatitis B vaccine in anti-HBs positive patients may be the primary reaction. Detection of HBV-DNA and HBsAg from anti-HBc-positive non-responders serum suggests that non-responders may be in a mild chronic condition.