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1958年Creech首次报告此法,由于效果不理想,未得到普遍重视和广泛应用。1974年McBride~2报通了1960年至1972年用此法治疗87例肢体恶性肿瘤。国内郑迺光等(1964)~3和林有泉等(1965)~4相继报道了区域性灌注与其效果进行肢体局部体外循环灌注高浓度化学药物,自1975年1月到1977年3月我们用此法共治疗下肢几种恶性肿瘤11例,近期效果较好。 此法是暂时阻断肿瘤区域与体循环的联系,然后用高浓度化学药物,由人工心肺机通过氧合袋灌注到肿瘤区域,使肿瘤细胞在短时间内得到致命的打击,而全身脏器及骨髓得到保护。 一、化学药物灌注的具体步骤 (一)人工心肺机系我院与天津电器厂协作试制的滚动泵型机器。人工肺用天津市医用的塑料鼓
In 1958, Creech reported this method for the first time. Due to unsatisfactory results, it has not received universal attention and has been widely used. In 1974, McBride~2 reported that it used this method to treat 87 cases of limb malignancy from 1960 to 1972. Domestic Zheng Dianguang et al. (1964)~3 and Lin Youquan et al. (1965)~4 have reported on regional perfusion and their effects on the localization of extracorporeal circulation with high concentrations of chemical drugs. We used this from January 1975 to March 1977. There were 11 cases of malignant tumors in the lower extremities. This method temporarily blocks the connection between the tumor area and the systemic circulation, and then uses a high-concentration chemical drug to be injected into the tumor area by an oxygenator bag by an artificial heart-lung machine, so that the tumor cells can be fatally attacked in a short time, and the whole-body organs and The bone marrow is protected. First, the specific steps of chemical medicine infusion (A) of the artificial heart-lung machine Department of Tianjin Institute of Electrical Appliances and the trial of the rolling pump-type machine. Tianjin Medical Medical Plastic Drum for Artificial Lung