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目的 :研究银杏叶提取物 (ExtractofGinkgoBilboa,EGB)对糖尿病大鼠肾脏的保护作用。方法 :应用EGB对四氧嘧啶糖尿病大鼠进行了8wk治疗 ,观察其对糖尿病大鼠肾脏的保护作用。结果 :EGB能明显提高血清及肾组织中超氧化物歧化酶 (SOD)及谷光甘肽过氧化物酶 (GSH -Px)活性 ,改善基底膜增厚及基质增生 ,减少实验大鼠肾脏尿蛋白排泄量 ,减轻肾功能损害。结论 :EGB在预防与治疗糖尿病肾病方面有一定作用。
Objective: To study the protective effect of Ginkgo biloba extract (Extract of Ginkgo Bilboa, EGB) on the kidney of diabetic rats. METHODS: Allergic diabetic rats were treated with EGB for 8 weeks and their protective effects on the kidneys of diabetic rats were observed. RESULTS: EGB could significantly increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum and kidney tissue, improve the thickening of basement membrane and matrix hyperplasia, and reduce the excretion of urinary protein in kidney of experimental rats. The amount reduces renal damage. Conclusion: EGB has a certain role in the prevention and treatment of diabetic nephropathy.