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目的:研究原癌基因c-met蛋白在人类喉癌组织中的表达,探讨c-met的蛋白表达与喉癌的临床病理特征之间的关系。方法:应用免疫组化SABC法检测80例人类喉癌组织标本及60例声带小结、息肉中c-met的蛋白表达,并行统计学分析。结果:原癌基因c-met蛋白在声带小结、息肉中的表达率为10％,在喉癌组织中的表达率为65％;c-met蛋白的表达与喉癌的临床分期、病理学分级、淋巴结转移均显著相关(P<0．01)。结论:原癌基因c-met蛋白在喉癌组织中高表达且与喉癌淋巴结转移、病理学分期、组织分级密切相关。
OBJECTIVE: To study the expression of c-met protein in human laryngeal carcinoma and to investigate the relationship between c-met protein expression and clinicopathological features of laryngeal carcinoma. Methods: Immunohistochemical SABC method was used to detect the protein expression of c-met in 80 cases of human laryngeal carcinoma and 60 cases of vocal nodules and polyps. Statistical analysis was performed. Results: The expression of protooncogene c-met protein was 10% in vocal nodules and polyps, and 65% in laryngeal carcinoma. The expression of c-met protein was correlated with the clinical stage, pathological grade , Lymph node metastasis were significantly related (P <0.01). CONCLUSION: The proto-oncogene c-met protein is highly expressed in laryngeal squamous cell carcinoma and is closely related to lymph node metastasis, pathological staging and histological grade of laryngeal cancer.