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本研究应用戊巴比妥钠诱发的犬急性心力衰竭模型,并设立生理盐水组和西地兰组,以比较黄连素组对心力衰竭的作用。静脉注射黄连素1mg/kg(3min内)+0.2mg·kg~(-1)·min~(-1)(维持30min)对戊巴比妥钠诱发的急性心力衰竭犬,有明显增加左室+dp/dt从103.6±25.8增加到250.9±45.0kPa/s(P<0.01),扩大心力环面积,逐渐降低左室舒张末期压,主动脉内收缩压不变,而舒张压下降,心率加快。在本研究中,黄连素对改善戊巴比妥钠引起的犬的心力衰竭比西地兰作用更明显。
In this study, pentobarbital sodium-induced acute heart failure model in dogs, and the saline group and cedilan group were established to compare the role of berberine group on heart failure. Intravenous injection of berberine 1mg / kg (within 3min) + 0.2mg · kg -1 (-1) (maintenance 30min) pentobarbital sodium-induced acute heart failure dogs, significantly increased left ventricular + dp / dt increased from 103.6 ± 25.8 to 250.9 ± 45.0 kPa / s (P <0.01). The area of annulus fibrosus was enlarged, the left ventricular end-diastolic pressure was gradually decreased, the aortic systolic pressure was unchanged, diastolic pressure was decreased and heart rate was increased . In this study, berberine was more effective than cedilanol on improving canine heart failure caused by pentobarbital sodium.