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目的:探讨影响慢性重型乙型肝炎预后的因素。方法:慢性重型乙型肝炎患者72例依预后分为好转组22例与无效组50例,分析两组临床资料。结果:无效组患者年龄偏大,多有肝硬化的基础,肝性脑病、上消化道出血、肝肾综合征、自发性腹膜炎发生率高,凝血酶原活动度低,AFP定量低;而HBVDNA定量在两组间无差异(P>0.05)。结论:年龄、失代偿性肝硬化、高胆红素血症、PTA%高低、AFP值,并发肝性脑病、肝肾综合征、自发性腹膜炎、电解质紊乱、消化道出血是影响慢性重型乙型肝炎预后的因素。
Objective: To explore the factors affecting the prognosis of chronic severe hepatitis. Methods: 72 cases of chronic severe hepatitis B patients were divided into remission group (n = 22) and ineffective group (n = 50) according to the prognosis. Clinical data of two groups were analyzed. Results: In the invalid group, the patients were older, had the basis of cirrhosis, hepatic encephalopathy, upper gastrointestinal bleeding, hepatorenal syndrome, high incidence of spontaneous peritonitis, low activity of prothrombin and low quantitative of AFP. HBVDNA Quantitative no difference between the two groups (P> 0.05). CONCLUSIONS: Age, decompensated cirrhosis, hyperbilirubinemia, PTA%, AFP values, concurrent hepatic encephalopathy, hepatorenal syndrome, spontaneous peritonitis, electrolyte disturbances, and gastrointestinal bleeding are the major causes of chronic severe B Hepatitis prognosis factors.