肝纤维化是慢性乙型肝炎向肝硬变发展的必经阶段 ,而且此阶段是可逆的病理过程。因此 ,寻找有效的抗纤维化药物是临床急待解决的问题。 1995～ 1999年我们观察重组干扰素α- 2 b对肝纤维化的作用 ,旨在探讨干扰素 α- 2 b抗纤维化的远期疗效。1　临床资料1.1　一般资料　病例为 Liver fibrosis is a necessary stage for the development of chronic hepatitis B to cirrhosis, and this stage is a reversible pathological process. Therefore, looking for effective anti-fibrosis drugs is an urgent clinical problem. From 1995 to 1999, we observed the effect of recombinant IFN-α-2b on hepatic fibrosis in order to explore the long-term effect of interferon α-2b on fibrosis. 1 clinical data 1.1 general information cases