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母亲免疫系统常对胎儿表达的父亲抗原产生应答,但胎儿不一定被排斥.胎儿的存活取决于胎母交界面组织的特性.例如孕鼠宫内的一个胎儿移植到其股肌中被排斥,而其余胎儿不受伤害.此外,同种基因的胚泡被置在预先免疫过的鼠肾包膜下被排斥,而放在有良好激素环境的子宫内会着床并发育.这些资料表明子宫内的局部因素在防止胚胎损坏方面起关键作用,蜕膜中存在局部非特异性抑制机理可促进胎儿存活而不影响母体全身免疫.近来已在鼠蜕膜中发现有非特异性抑制活性的细
The mother’s immune system often responds to the fetal antigens expressed by the fetus, but the fetus is not necessarily rejected. The survival of the fetus depends on the characteristics of the maternal interface tissue. For example, a fetus in a pregnant rat intrauterine organ transplanted into its femoral muscle is rejected, While the rest of the fetuses were uninjured.In addition, blastocysts of the same gene were rejected in the pre-immunized rat renal capsule and implanted in the uterus in a well-hormone-tolerant environment and developed.These data suggest that the uterus Local factors within the embryo play a key role in preventing embryonic damage and there is a mechanism of local non-specific inhibition of decidualization that promotes fetal survival without affecting maternal systemic immunity. Recently, a non-specific inhibitory activity has been found in rat decidua