论文部分内容阅读
目的:观察2型糖尿病肾病(DN)患者血清肝细胞生长因子(hepatocyte growth factor,HGF)和肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的水平变化,探讨其在DN中的临床意义。方法:2006年1月至2009年12月入我院治疗的2型糖尿病患者88例(糖尿病非DN组30例、早期DN组26例、临床期DN组20例、终末期DN组12例)采用ELISA方法检测患者血清中肝细胞生长因子(HGF)和肿瘤坏死因子-α(TNF-α)含量,并与同期50例健康对照组比较。结果:(1)2型糖尿病组血清HGF及TNF-α水平显著高于健康对照组(P<0.01);(2)2型糖尿病各组血清HGF及TNF-α水平随糖尿病肾病的严重程度加重而增加,各组间差异均有统计学意义(P均<0.01);(3)2型糖尿病各组血清HGF及TNF-α水平呈显著正相关(r=0.786,0.725,0.817,0.802,P<0.05).结论:血清HGF及TNF-α水平在糖尿病肾病发病中起重要作用,并且和糖尿病肾病的分期密切相关。
Objective: To observe the changes of serum levels of hepatocyte growth factor (HGF) and tumor necrosis factor-α (TNF-α) in patients with type 2 diabetic nephropathy (DN) Clinical significance. Methods: From January 2006 to December 2009, 88 patients with type 2 diabetes mellitus (30 non-DN diabetic patients, 26 early DN patients, 20 DN patients in clinical stage and 12 patients in terminal DN group) Serum levels of hepatocyte growth factor (HGF) and tumor necrosis factor-α (TNF-α) were detected by ELISA, and compared with 50 healthy controls at the same period. Results: (1) The levels of serum HGF and TNF-α in type 2 diabetes mellitus group were significantly higher than those in healthy control group (P <0.01); (2) The levels of serum HGF and TNF-α in type 2 diabetes mellitus group were increased with the severity of diabetic nephropathy (P <0.01). (3) The levels of serum HGF and TNF-α in each group were significantly and positively correlated with each other (r = 0.786,0.725,0.817,0.802, P <0.05) .Conclusion: Serum levels of HGF and TNF-α play an important role in the pathogenesis of diabetic nephropathy and are closely related to the stage of diabetic nephropathy.