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目的观察草酸铂联合氟脲嘧啶及醛氢叶酸同步放化疗治疗局部晚期鼻咽癌的疗效及毒副反应,探讨该方案的临床可行性。方法36例T3～4N2～3MO局部晚期鼻咽癌患者进入综合治疗组,分别在放疗第1、22、43天接受草酸铂130mg/m2+5-氟脲嘧啶3.75mg/m2+醛氢叶酸100mg/m2同步化疗。选取32例单纯放疗者为对照组。结果所有患者如期完成治疗。结论草酸铂联合氟脲嘧啶及醛氢叶酸同步化放疗,可明显提高晚期鼻咽癌患者颈淋巴结转灶局控率,对鼻咽原发灶的控制也有一定帮助;对其毒性反应患者可耐受,未影响放疗的顺利完成。
Objective To observe the curative effect and side effects of oxaliplatin combined with fluorouracil and alformin concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma and to explore the clinical feasibility of this regimen. Methods Thirty-six patients with T3 ~ 4N2 ~ 3MO local advanced nasopharyngeal carcinoma (NPC) were enrolled in the comprehensive treatment group and received oxaliplatin 130mg / m2 + 5- fluorouracil 3.75mg / m2 + m2 simultaneous chemotherapy. 32 cases of radiotherapy alone as the control group. Results All patients completed the treatment on schedule. Conclusions The combination of oxaliplatin and fluorouracil and alformin simultaneously improves the control rate of cervical lymph node metastasis in patients with advanced nasopharyngeal carcinoma and may be helpful in the control of primary nasopharyngeal carcinoma. By, did not affect the successful completion of radiotherapy.