小白鼠腹腔注射硅胶悬液,使巨噬细胞中毒、死亡以阻断巨噬细胞的机能。结果在雌性小白鼠,实体型肉瘤180和肝癌的生长明显加快,向周围组织浸润也更广泛,在雄性小白鼠则无明显变化。推测系因雌性小白鼠对瘤细胞的抑制或杀伤作用较雄性更多依赖(直接或间接)于巨噬细胞的机能之故。 The mice were injected intraperitoneally with a suspension of silica gel, which caused macrophage poisoning and death to block the function of macrophages. Results In female mice, the growth of solid sarcoma 180 and hepatocellular carcinoma was significantly faster, and the infiltration into the surrounding tissues was more extensive, and there was no significant change in the male mice. It is speculated that the inhibition or killing of tumor cells by female mice is more dependent (directly or indirectly) on the function of macrophages than males.