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目的:探讨雌激素受体( E R)、孕激素受体( P R)及cerb B2 在乳腺癌中的表达。方法:应用免疫组织化学技术对 114 全乳腺癌的 E R、 P R及 cerb B2 基因表达进行研究。结果:58 例 E R、 P R 阳性中cerb B2 表达12 例(27% );56 例 E R、 P R 阴性中cerb B2 表达26 例(464% ),两者比较差异有显著性( P< 0.05)。在38 例cerb B2 表达病例中,26 例发生淋巴结癌转移(684% ),在76 例cerb B2 不表达的病例中,16 例淋巴结癌转移(212% )。结论:cerb B2 表达与 E R、 P R 水平呈岁相关,cerb B2 表达与淋巴结癌转移呈正相关。cerb B2 过度表达与乳腺癌预后有关,即阳性细胞越多,死亡、复发和转移的机率也越高。
Objective: To investigate the expression of estrogen receptor (ER), progesterone receptor (PR) and c-erb B2 in breast cancer. METHODS: Immunohistochemistry was used to study the expression of E R, P R and cerb B2 genes in 114 patients with breast cancer. RESULTS: There were 12 cases of C-erb B2 expression (2.8%) in 58 cases of E R and P R positive, and 26 cases (46.4%) of C-erb B2 in 56 cases of E R and P R negative. The difference was significant (P < 0.05). In 38 cases of c-erb B2 expression, 26 cases of lymph node metastasis (68.4%) occurred, and in 76 cases of c-erb B2 non-expression, 16 cases of lymph node metastasis (21. 2%). CONCLUSIONS: c-erb B2 expression is age-related with E R, P R levels, and c-erb B2 expression is positively correlated with lymph node metastasis. c erb B2 overexpression is associated with the prognosis of breast cancer, that is, the more positive cells, the higher the chance of death, recurrence, and metastasis.