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由于免疫技术的应用,发现鼻腔粘膜内存在着多种生物活性多肽,尤以血管活性肠肽(VIP)含量最为丰富。VIP具有广泛而重要的生物活性,因而引起许多学者的重视。本文就VIP在鼻腔的分布、功能及临床意义综述如下。 VIP(vasoactive intestinal po1ypeptide)即血管活性肠多肽,由28个氨基酸组成。1970年由Said等人从猪小肠中提纯,并被认为是一种肽类激素,具有广泛的生物学特性,包括引起全身血管扩张,血压降低,心输出量增加,呼吸兴奋和血糖增高等。应用免疫学新技术,已证明VIP存在于神经细胞中,在电镜下观察到神经轴突末梢存在着呈圆形的VIP颗粒。VIP
Due to the application of immunological techniques, there are many bioactive peptides found in nasal mucosa, especially vasoactive intestinal peptide (VIP). VIP has a wide range of important biological activity, which attracted many scholars attention. This article on the distribution of VIP in the nasal cavity, function and clinical significance are summarized below. VIP (vasoactive intestinal po1ypeptide) that vasoactive intestinal polypeptide, composed of 28 amino acids. Said in 1970 by Said et al purified from pig intestine and is considered to be a peptide hormone, has a wide range of biological properties, including systemic vasodilatation, decreased blood pressure, cardiac output, respiratory excitement and increased blood sugar. Application of new immunological technology, VIP has been shown to exist in nerve cells, electron microscopy was observed at the end of the axon round VIP particles exist. VIP