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目的探讨人表皮生长因子受体2(HER-2/neu)原癌基因在胃癌组织中的表达及其临床意义。方法检测55例胃癌患者术后标本中HER-2/neu的表达,分析其在不同组织类型胃癌中的表达差异及其与临床病理的相关性。结果55例胃癌组织中,HER-2/neu表达阳性率43.6%(24/55),其在不同组织类型的胃癌中表达无统计学差异(P>0.05)。HER-2/neu的表达与胃癌浸润深度、淋巴结转移和临床分期密切相关(r=0.375,r=0.380和r=0.488,P<0.05)。HER-2/neu表达阳性的患者无病生存期及总生存期均低于表达阴性者(P<0.05)。结论 HER-2/neu在胃癌组织中的表达与其生物学行为密切相关;检测HER-2/neu表达对胃癌治疗的选择和预后的评估有一定意义。
Objective To investigate the expression of human epidermal growth factor receptor 2 (HER-2 / neu) proto-oncogene in gastric carcinoma and its clinical significance. Methods The expression of HER-2 / neu in specimens of 55 patients with gastric cancer was detected by immunohistochemistry and their correlation with clinical pathology was analyzed. Results The positive rate of HER-2 / neu in 55 cases of gastric carcinoma was 43.6% (24/55), which showed no significant difference in different types of gastric cancer (P> 0.05). The expression of HER-2 / neu was closely related to the depth of invasion, lymph node metastasis and clinical stage (r = 0.375, r = 0.380 and r = 0.488, P <0.05). Patients with positive HER-2 / neu expression had lower disease-free survival and overall survival than those with negative expression (P <0.05). Conclusion The expression of HER-2 / neu in gastric cancer is closely related to its biological behavior. Detecting the expression of HER-2 / neu has some significance in the evaluation of the choice and prognosis of gastric cancer.