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由于肟醚结构的特殊性质,因而很多农药和医药化合物中包含该结构.介绍苯乙酮肟醚类化合物的合成、瓜类白粉病抑制活性的定量构效关系(QSAR)研究以及基于QSAR研究结果的新化合物设计、合成和生测,尝试了农药先导合理设计流程在具有瓜类白粉病抑制活性的苯乙酮肟醚类化合物设计中的应用.初步的结果显示,介绍的工作模式既充分利用了原来的工作基础,又降低了失败的风险、污染和成本.
Due to the special nature of the oxime ether structure, many pesticides and pharmaceutical compounds are involved in the structure.The quantitative QSAR (QSAR) studies on the synthesis of acetophenone oxime ethers, the inhibitory activity of melon powdery mildew and the results based on QSAR Of the new compound design, synthesis and bioassay, try to pesticide pilot rational design flow in melon powdery mildew inhibitory activity of acetophenone oxime ether compounds design.Preliminary results show that the mode of operation is not only fully utilized The basis of the original work, but also reduces the risk of failure, pollution and costs.