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目的:对肺癌组织中MGMT蛋白的表达情况进行检测,并对其与吸烟患者的关系进行探讨。方法:选取2009年10月~2011年10月入住我院胸外的肺癌患者93例,并根据患者是否有长期吸烟史将患者分为吸烟组以及非吸烟组,吸烟组患者共62例;非吸烟组患者共31例,并采用免疫组织化学法对这93例患者肺组织中的MGMT蛋白的表达情况进行检测。结果:吸烟组MGMT蛋白阳性表达率为63.3%,非吸烟组MGMT蛋白阳性表达率为28.1%,两者之间有明显差异(P<0.05)。吸烟组MGMT蛋白表达评分为(2.69±1.08)分,非吸烟组MGMT蛋白表达评分为(1.49±1.09),两者之间有明显差异(P<0.05)。结论:肺癌组织中MGMT蛋白的表达情况与患者的吸烟习惯密切相关,有吸烟习惯的患者,其MGMT蛋白的表达越活跃。
Objective: To detect the expression of MGMT protein in lung cancer and explore the relationship between MGMT protein and smoking in patients with lung cancer. Methods: Ninety-three patients with lung cancer admitted to our hospital from October 2009 to October 2011 were selected and divided into smoking group and non-smoking group according to whether patients had long-term smoking history. A total of 62 patients were smoked. A total of 31 smokers were enrolled in this study. The expression of MGMT protein in lung tissues of 93 patients was detected by immunohistochemical method. Results: The positive expression rate of MGMT protein in smoking group was 63.3%, while that in non-smoking group was 28.1%. There was a significant difference between the two (P <0.05). The smoking MGMT protein expression score (2.69 ± 1.08) points, non-smoking MGMT protein expression score (1.49 ± 1.09), there was a significant difference between the two (P <0.05). CONCLUSION: The expression of MGMT protein in lung cancer is closely related to the smoking habits of patients. In patients with smoking habit, the expression of MGMT protein is more active.