Holt—Oram综合征为一先天性心脏畸形合并上肢骨骼畸形的遗传病,本文报告一例。患者,女,25岁。未婚,于5岁因“麻疹”住院时发现“心脏病”,当时不发绀,活动与同龄儿童无异,无经常感冒、肺炎史。16岁以后走山路时感心跳,气短,有易疲劳,背痛等症状。近两年来心跳、气短加重。1982年4月12日因先心病、房缺收 Holt-Oram syndrome is a genetic congenital heart disease with upper limb skeletal deformity, this article reports a case. Patient, female, 25 years old. Unmarried, at the age of 5 due to “measles” hospitalized found “heart disease”, then no cyanosis, activities and children of the same age is no different, no common cold, history of pneumonia. 16-year-old walking after the mountain heartbeat, shortness of breath, fatigue, back pain and other symptoms. The past two years, heart rate, shortness of breath worse. April 12, 1982 due to congenital heart disease, lack of room closing