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目的探讨儿童急性淋巴细胞白血病(ALL)与母亲怀孕期间溶剂、油漆、石油接触及吸烟的关系。方法检索Pubmed、Embase、the Cochrane library和Web of Science数据库中的相关文献,对母亲孕期接触苯和儿童急性淋巴细胞白血病的风险之间的优势比和95%的置信区间进行评估。结果 Meta分析结果显示母亲怀孕期间溶剂、油漆和石油暴露与儿童急性淋巴细胞白血病之间的关系差异有统计学意义,OR及95%CI分别为[1.25(1.09,1.45)],[1.23(1.02,1.47)],[1.42(1.10,1.84)]。而母亲怀孕期间吸烟与儿童急性淋巴细胞白血病之间的关系差异无统计学意义,OR及95%CI为[0.99(0.93,1.06)]。结论母亲怀孕期间接触溶剂、油漆和石油与儿童患急性淋巴细胞白血病之间的关系差异有统计学意义,尚不能得出母亲怀孕期间吸烟与儿童急性淋巴细胞白血病的关系差异有统计学意义。母亲怀孕期间避免环境和职业接触苯可降低儿童急性淋巴细胞白血病的发病风险。
Objective To investigate the relationship between childhood acute lymphoblastic leukemia (ALL) and mother’s solvent, paint, petroleum contact and smoking during pregnancy. METHODS: Relevant articles from Pubmed, Embase, the Cochrane library, and Web of Science databases were searched to determine the odds ratio and the 95% confidence interval between maternal exposure to benzene and childhood acute lymphoblastic leukemia. Results The results of Meta analysis showed that there was significant difference in the relationship between solvent, paint and oil exposure and acute lymphoblastic leukemia in children during pregnancy. The OR and 95% CI were [1.25 (1.09, 1.45)] and [1.23 (1.02 , 1.47)], [1.42 (1.10, 1.84)]. There was no significant difference in the relationship between maternal smoking and childhood acute lymphoblastic leukemia, OR and 95% CI [0.99 (0.93, 1.06)]. Conclusion The relationship between mother’s exposure to solvents, paints and oils and childhood acute lymphoblastic leukemia is statistically significant. There is no significant difference between the mother’s smoking and childhood acute lymphoblastic leukemia during pregnancy. Avoid exposure of mother and mother to benzene during pregnancy reduce the risk of developing acute lymphoblastic leukemia in children.