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白血病是来源于造血系统的一种恶性肿瘤,好发于儿童和青少年,其病因和发病机制尚不完全清楚,但病毒病因学较受重视。人疱疹病毒6型(HHV-6)是1986年发现的疱疹病毒科中的一个新成员。研究发现,HHV-6的感染与淋巴瘤的发生有一定关系,在白血病患者中具有较高的感染率。为了探讨HHV-6感染与白血病的关系,我们采用间接免疫荧光试验(IFA)和PCR,分别检测了白血病患者血清抗HHV-6 IgG和外周血单个核细胞(PBMC)中HHV-6 DNA的序列。1材料和方法1.1材料血清及PBMC标本,采自第四军医大学西京医院血液内科住院患者,共37例,即白血病22例(男17例,女5
Leukemia is a malignant tumor derived from the hematopoietic system and occurs in children and adolescents. The etiology and pathogenesis of leukemia are not yet fully understood, but the etiology of the virus is more valued. Human herpesvirus 6 (HHV-6) is a new member of the herpesvirus family discovered in 1986. The study found that, HHV-6 infection and lymphoma have a certain relationship, in patients with leukemia has a high infection rate. To investigate the relationship between HHV-6 infection and leukemia, we used indirect immunofluorescence assay (IFA) and PCR to detect the sequence of HHV-6 DNA in serum anti-HHV-6 IgG and PBMC from leukemia patients . 1 Materials and Methods 1.1 Materials Serum and PBMC specimens were collected from Xijing Hospital of Fourth Military Medical Hospital, Department of Hematology, a total of 37 cases, that is, 22 cases of leukemia (17 males and 5 females