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给15名患有全身性淋巴结病和人免疫缺陷病毒(HIV)血清阳性但无症状的男同性恋者口服三氮唑核苷,疗程2～4周,剂量分别为每天600、1200或2400 mg,观察本品在此类患者中的血浆浓度、不良反应、抗病毒作用及其免疫增强效应。结果表明:患者以①每天1200或2400mg,连服2周,②每天2400 mg负荷量连服3天,随之以每天600 mg的维持量连用4周,均可使血浆药物坪值>6μmol/L,从而达到抑制HIV中RNA指导的DNA聚合酶(转录酶)活性的效应,转录酶活性平均降低约58%(38～82%) 三氮唑核苷口服生物利用度为45%,很
Ribavirin was given orally to 15 gay but seronegative, asymptomatic gonorrhea patients with systemic lymphadenopathy and human immunodeficiency virus (HIV) for 2 to 4 weeks at doses of 600, 1200 or 2400 mg daily, Observe this product in such patients in plasma concentrations, adverse reactions, antiviral effects and immune enhancement effect. The results showed that: patients with daily 1,200 or 2,400 mg, and even served 2 weeks, 2 daily dose of 2400 mg with service for 3 days, followed by the maintenance dose of 600 mg daily for 4 weeks, can make the plasma drug Ping> 6μmol / L, thereby achieving the effect of inhibiting RNA-guided RNA polymerase (transcriptase) activity in HIV, with an average reduction in transcriptase activity of about 58% (38-82%). The oral bioavailability of ribavirin was 45%