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细胞遗传学和分子遗传学的研究证实 ,70 %～ 80 %套细胞淋巴瘤 (MCL)中可以检测到t(11;14 ) (q13;q32 ) [1 3 ] ,易位使位于 11q13上的bcl 1癌基因 (也称为PRAD1,parathyroidadenomatosis,甲状旁腺腺瘤病或CCND1)处于 14 q32上IgH基因增强子的调控下 ,从而被激活 ,使其编码的细
Studies in cytogenetics and molecular genetics have shown that t (11; 14) (q13; q32) can be detected in 70% to 80% of mantle cell lymphoma (13) [13] The bcl 1 oncogene (also known as PRAD1, parathyroidadenomatosis, parathyroid adenoma or CCND1) is under the control of the IgH gene enhancer on 14 q32 and is therefore activated to make it encode a fine