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目的以数学模型描述感染日本血吸虫(中国大陆株)的小鼠阳性粪便虫卵数的时间动力学分布规律。方法自血吸虫感染小鼠后第5周至第11周,每周收集24 h粪便1次,并计数每克粪样中的虫卵数(EPG)。EPG的均数m≥400时,利用回归方程lg(v)=a+blg(m)的回归系数b是否接近2,来判断粪虫卵是否服从负二项分布。结果剔除EPG为0的结果,组内小鼠EPG在同一时间点上呈正态分布。取各时间点小鼠粪EPG的均值m,分别构建C57BL/6与BALB/c小鼠阳性粪样便EPG的回归方程,显示全部阳性粪样的方程系数b分别为1.72和1.39,连续7次阳性鼠粪EPG的回归方程系数b分别为1.71和1.26。结论实验室感染日本血吸虫的C57BL/6与BALB/c小鼠,粪虫卵的时间的分布均可以负二项分布来描述,但C57BL/6小鼠粪虫卵数随时间分布的拟合优度高于BALB/c。
Objective To describe the temporal dynamics of the number of mouse positive stool eggs infected with Schistosoma japonicum (Chinese strain) with mathematical models. Methods From the 5th week to the 11th week after infection of schistosomiasis mice, fecal samples were collected once a week for 24 hours and the number of eggs per gram of fecal samples was counted. When the average number of EPGs m ≧ 400, whether the fecal eggs obey negative binomial distribution is judged by whether the regression coefficient b of the regression equation lg (v) = a + blg (m) is close to 2. Results Excluding the results of EPG as 0, the EPG of mice in the group showed a normal distribution at the same time point. The mean m of EPG of mice at each time point was taken to construct the regression equation of EPG of positive stool samples of C57BL / 6 and BALB / c mice, respectively, showing that the coefficient b of the positive samples for all positive samples were 1.72 and 1.39 respectively, The regression equation coefficients b for positive mouse feces EPG were 1.71 and 1.26, respectively. Conclusion The time distribution of C57BL / 6 and BALB / c mice infected with Schistosoma japonicum in laboratory can be described by negative binomial distribution. However, the distribution of the number of eggs in C57BL / 6 mice over time is good Degree higher than BALB / c.