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随着研究的不断深入,血浆高同型半胱氨酸血症已被证实是脑梗死发病的独立危险因数,尤其是在中青年脑梗死,复发性脑梗死中起至关重要的作用,本文就血浆高同型半胱氨酸血症与脑梗死的相关性及干预措施作一简要阐述。1血浆高同型半胱氨酸血症(HHcy)1.1同型半胱氨酸(Hcy)在体内代谢和测定Hcy是体内3种含硫氨基酸之一,是蛋氨酸循环和半胱氨酸代谢的重要中间产物,在体内代谢共有3条途径。①再甲基化途径,约有50%的Hcy在甲硫氨酸合成酶催化下以维生素B12作为辅酶,以N5甲基四氢叶酸为甲基供体,
With the deepening of research, plasma hyperhomocysteinemia has been proved to be an independent risk factor for the incidence of cerebral infarction, especially in young and middle-aged cerebral infarction, recurrent cerebral infarction plays a crucial role, this article Plasma hyperhomocysteinemia and cerebral infarction and interventions for a brief description. 1 Hyperhomocysteinemia (HHcy) 1.1 Homocysteine (Hcy) metabolism and determination in vivo Hcy is one of the three sulfur-containing amino acids in the body and is an important intermediate of methionine cycle and cysteine metabolism Products, metabolism in the body a total of three ways. ① remethylation pathway, about 50% of Hcy in the methionine synthase catalyzed by vitamin B12 as a coenzyme, N5 methyl tetrahydrofolate as a methyl donor,