糖尿病患者常并发慢性周围神经病变,表现为感觉异常。一氧化氮(NO)缺乏导致周围神经供血不足以及由此引起的感觉传导异常可能与之有关。但对于中枢神经是否参与感觉障碍?与糖尿病时感觉传导异常的关系如何,仍有许多未知。中脑导水管周围灰质(PAG)是内源性镇痛系统的关键结构,其背外侧区富含神经元型一 Diabetic patients often complicated by chronic peripheral neuropathy, manifested as sensory abnormalities. Lack of nitric oxide (NO) may result in insufficient peripheral blood supply and sensory conduction abnormalities that may be associated with it. However, there is still a lot of unknown whether CNS is involved in sensory disturbances or not and how sensory conduction abnormalities are associated with diabetes mellitus. Periaqueductal gray (PAG) is the key structure of endogenous analgesic system, the dorsolateral region is rich in neuronal type