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目的 探讨多灶性运动神经病 (MMA)的临床特点、神经电生理及病理变化的特异性。方法 结合文献分析 4例MMN的临床资料、肌电图、病理特征及治疗结果。结果 MMN的临床表现为慢性、非对称性远端肢体无力 ;电生理检查以运动神经传导阻滞或部分阻滞为特点 ;病理学特征为运动神经局灶性脱髓鞘性改变。结论 MMN应与运动神经元病和慢性炎性脱髓鞘性多发性神经根神经病鉴别。可采用免疫球蛋白治疗
Objective To investigate the clinical features, electrophysiological and pathological changes of multifocal motor neuropathy (MMA). Methods The clinical data, EMG, pathological features and treatment outcome of 4 cases of MMN were analyzed in combination with the literature. Results The clinical manifestations of MMN were chronic and non-symmetrical distal limb weakness. The electrophysiological examination was characterized by motor nerve block or partial block. The pathological features were focal demyelination of motor nerve. Conclusion MMN should be differentiated from motor neuron disease and chronic inflammatory demyelinating multiple neuropathy. Immunoglobulin therapy can be used