110例应用OAD血糖控制不理想的T2DM患者随机分为甘精胰岛素组(n=50)和预混胰岛素组(n=60)。甘精胰岛素组采用三餐时各嚼服50～100mg阿卡波糖,每晚10点注射甘精胰岛素。预混胰岛素组采用早、晚餐前30min皮下注射。结果治疗后两组HbA1c及FBG、PPG均较前明显下降,两组下降度比较无统计学意义,但甘精组低血糖事件明显少于预混组。结论甘精胰岛素联合口服阿卡波糖可能良好地控制高血糖,且低血糖发生率低。 One hundred and ten patients with T2DM who did not control OAD glycemic control were randomly assigned to insulin glargine group (n = 50) and premixed insulin group (n = 60). Glargine group of three meals a day when chewing 50 to 100mg acarbose, ghrelin at 10 o’clock injection. Pre-mixed insulin group using early, subcutaneous injection 30min before dinner. Results After treatment, HbA1c, FBG and PPG in both groups were significantly decreased compared with those before treatment. There was no significant difference in descending degree between the two groups. However, the hypoglycemic events in Gan Gan group were significantly less than those in the premixed group. Conclusion Glargine and oral acarbose may control hyperglycemia with low incidence of hypoglycemia.