论文部分内容阅读
目的 探讨精神分裂症发作期与缓解期患者肠道菌群的差异. 方法 选择精神分裂症急性发作期患者12例为发作组,与其性别、年龄、BMI匹配的精神分裂症缓解期患者13例为对照组,采集患者粪便标本进行16S rRNA基因高通量测序,分析两组肠道菌群的差异. 结果 发作组肠道菌群chao指数(t=2.385,P=0.026)和ace指数(t=3.068,P=0.005)低于对照组;发作组肠道菌群中拟杆菌属相对丰度高于对照组(Z=-2.013, P=0.044),而普氏菌属相对丰度低于对照组(Z=-3.427,P=0.001).患者普氏菌属相对丰度与PANSS评分呈负相关(r=-0.577,P=0.003).结论 精神分裂症发作期患者与缓解期患者相比肠道菌群发生改变,且菌群与精神症状存在关联.“,”Objective To investigate the differences of gut microbiota in patients with schizophrenia between onset and remission. Methods Twelve patients with schizophrenia in the stage of onset were selected as the episode group. Thirteen gender-, age-and BMI-matched patients with schizophrenia during the remission period were selected as the control group. The fecal specimens of the two groups were collected for high-throughput sequencing of the 16S rRNA gene, and the gut microbiota differences between the two groups were analyzed. Results The chao index and ace index of gut microbiota was lower in the episode group than in the control group (t=2.385,P=0.026; t=3.068,P=0.005). The relative abundance of Bacteroides was higher and the relative abundance of Prevotella was lower in the episodes group than in the control group (Z=-2.013, P =0.044; Z=-3.427, P=0.001). The relative abundance of the Prevotella was negatively correlated with the PANSS score (r=-0.577, P=0.003). Conclusion Schizophrenia in the stage of acute episode have altered gut microbiota compared with those in the stage of remission and the gut microbiota is significantly corrected with mental symptoms.