口咽念珠菌病是HIV感染者的常见口腔表现。现有的口腔内局部使用的抗真菌药物在口腔内很快会被清除,故每天需给药 3~5次。为延长抗真菌药物在口腔内的有效抗菌药物浓度的持续时间,研制出一种硝酸咪康唑口腔黏膜黏附含片,其在口腔有效抗菌持续时间比咪康唑凝胶长 5倍。375例HIV Oropharyngeal candidiasis is a common oral manifestation of HIV-infected persons. The existing intra-oral anti-fungal drugs that are used locally will be quickly removed in the oral cavity. Therefore, it is necessary to administer 3 to 5 times daily. In order to prolong the duration of antimicrobial effective antimicrobial concentration in the oral cavity, a miconazole nitrate buccal mucosa adhesive patch has been developed which has an effective oral antibacterial duration of 5 times longer than that of the miconazole gel. 375 cases of HIV