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目的探析舍曲林治疗脑梗死后抑郁对患者生活质量及抑郁程度的影响。方法选择嵩县中医院2012年7月至2015年4月收治的79例脑梗死后抑郁患者作为研究对象,依随机数字表法分为观察组(n=40)与对照组(n=39)。对照组予以森田疗法干预,观察组在对照组基础上应用盐酸舍曲林,比较两组治疗前后SF-36评分、HAMA评分及不良反应发生率。结果两组治疗前SF-36评分、HAMA评分比较差异未见统计学意义(P>0.05);治疗后观察组SF-36评分高于对照组、HAMA评分低于对照组,差异有统计学意义(P<0.05)。对照组无不良反应,观察组为7.5%,差异未见统计学意义(P>0.05)。结论舍曲林在脑梗死后抑郁患者中的应用可大幅缓解抑郁情绪并提高生活质量,为安全、有效的治疗药物,应用价值高。
Objective To investigate the effect of sertraline on the quality of life and the degree of depression in patients with cerebral infarction after depression. Methods Seventy-nine patients with post-stroke depression who were admitted to Songxian Hospital of Traditional Chinese Medicine from July 2012 to April 2015 were divided into observation group (n = 40) and control group (n = 39) according to random number table. . The control group was treated with Morita therapy. The observation group was given sertraline hydrochloride on the basis of the control group. The SF-36 scores, HAMA scores and incidence of adverse reactions were compared between the two groups before and after treatment. Results The scores of SF-36 and HAMA before treatment in both groups showed no significant difference (P> 0.05). After treatment, SF-36 score of observation group was higher than that of control group, HAMA score was lower than that of control group, the difference was statistically significant (P <0.05). No adverse reactions in the control group, the observation group was 7.5%, the difference was not statistically significant (P> 0.05). Conclusion Sertraline in patients with depression after cerebral infarction can greatly alleviate the depression and improve the quality of life, for the safe and effective treatment of drugs, high value.