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暴发性肝功能衰竭(FHF)患者血清中人肝细胞生长因子(hHGF)活性明显高于其它肝病患者,其活性与昏迷程度平行,疾病好转时迅速下降到接近正常。这提示 FHF 患者血清 hHGF 水平可作为肝功能不良的指标。hHGF 可能参与肝再生的自我防卫机理。作者从 FHF 患者血清中提纯出 hHGF,并用一种高特异性和敏感性的酶联免疫吸附法
Serum levels of human hepatocyte growth factor (hHGF) in patients with fulminant hepatic failure (FHF) are significantly higher than those in other liver disease patients, and their activity is in parallel with coma and rapidly falls to near normal when the disease improves. This suggests that serum hHGF levels in patients with FHF can be used as an indicator of liver dysfunction. hHGF may participate in the self-defense mechanism of liver regeneration. The authors purify hHGF from serum of patients with FHF and use a highly specific and sensitive enzyme-linked immunosorbent assay