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Objective:To investigate the effect of parecoxib sodium preemptive analgesia on postoperative pain and stress response in patients with laparoscopic surgery. Methods:118 patients with asymptomatic gallbladder polyps who underwent elective laparoscopic surgery in our hospital between January 2018 and January 2019 were divided into the control group (n=59) and the preemptive analgesia group (n=59) by random number table. Control group received routine total intravenous anesthesia, and preemptive analgesia group received intravenous injection of parecoxib sodium 0.7mg/kg during anesthesia induction. The differences in serum levels of pain mediators [prostaglandin E2 (PGE2), substance P (SP) and neuropeptide Y (NPY)], inflammatory factors [interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-12 (IL-12)] as well as stress mediators [cortisol (Cor), norepinephrine (NE) and epinephrine (E)] at before surgery (T0), 30min after extubation (T1), 6h after surgery (T2) and 24h after surgery (T3) were compared between the two groups of patients. Results:At T0, there was no significant difference in VAS score as well as inflammatory factor or stress mediator levels between the two groups (P>0.05). At T1, T2 and T3, VAS scores of the preemptive analgesia group were lower than those of the control group; serum IL-1β, IL-6, IL-12 and TNF-α levels were lower than those of the control group; serum Cor, NE and E levels were lower than those of the control group (P<0.05). Conclusion:Parecoxib sodium preemptive analgesia has a positive effect on reducing postoperative pain and systemic stress in patients with laparoscopic cholecystectomy.