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川芎嗪(80mg/kg体重)及酚苄明(0.25mg/kg体重)扩张肺血管,增加心输出量,抑制缺氧性肺血管收缩,而且对体循环的影响较小;汉防已甲素(1.85mg/kg体重)减慢心率,降低体肺循环压力及阻力,也能减弱缺氧性肺血管收缩;酚妥拉明虽然迅速降低体肺循环的压力和阻力,但不能减弱缺氧性肺血管收缩。这提示川芎嗪及酚苄明对缓解肺动脉高压,改善心功能可能疗效较好。
Ligustrazine (80 mg/kg body weight) and phenoxybenzamine (0.25 mg/kg body weight) dilate pulmonary vasculature, increase cardiac output, inhibit hypoxic pulmonary vasoconstriction, and have little effect on systemic circulation; Hancine (A) 1.85mg/kg body weight) slow down the heart rate, reduce the pressure and resistance of the pulmonary circulation, can also reduce the hypoxic pulmonary vasoconstriction; phentolamine can not reduce the pulmonary vasoconstriction of the hypoxic pulmonary vascular contraction although it rapidly reduces the pressure and resistance of the pulmonary circulation . This suggests that ligustrazine and phenoxybenzamine may have a good effect in alleviating pulmonary hypertension and improving cardiac function.