目的:制备氯化钾缓释片并考察其释药机制。方法:采用正交试验,以体外累积释药率为指标,优选包衣材料聚丙烯酰胺树脂及滑石粉的工艺参数。结果:以聚丙烯酰胺树脂4g/100g氯化钾、滑石粉用量7.5%为优化工艺所制氯化钾缓释片体外释放按零级模式释药。2、4、8h累积释药率分别大于26%、42%和94%,符合2005年版《中国药典》相关规定。结论:所制备缓释片工艺合理,体外释药效果良好。 Objective: To prepare potassium chloride sustained-release tablets and investigate the mechanism of drug release. Methods: Using orthogonal test, the cumulative release rate in vitro as an index, the preferred coating material polyacrylamide resin and talc process parameters. Results: The in vitro release of potassium chloride sustained-release tablets made of polyacrylamide resin 4g / 100g potassium chloride and 7.5% talcum powder was released in zero-order mode. 2,4,8h cumulative release rates were greater than 26%, 42% and 94%, in line with the 2005 edition of “Chinese Pharmacopoeia” the relevant provisions. Conclusion: The prepared sustained-release tablets have reasonable process and good in vitro release.