英国的病理学家Barrett 氏于1950年详细地论述了食管下端的慢性溃疡与食管炎的病理,提出了这种溃疡发生于先天性短食管所致突入到纵隔腔内的胃粘膜上的观点。1957年Barrett 氏进一步明确了这种食管下端粘膜为柱状上皮,它可能是食管粘膜上皮胚胎发育异常的结果。虽然Barrett 氏的观点不完全正确,但由于是他最先注意到这种病的病理特征,并发表了详细的研究论 Barrett, a British pathologist, detailed the pathology of chronic ulcers and esophagitis at the lower esophagus in 1950 and proposed the idea that this ulcer occurs in the gastric mucosa that protrudes from the congenital short esophagus into the mediastinal space. In 1957, Barrett’s further clarified that the lower esophageal mucosa is columnar epithelium, which may be the result of abnormal embryonic development of esophageal epithelium. Although Barrett’s view is not entirely correct, he is the first to notice the pathological features of the disease and publishes detailed research theories.