论文部分内容阅读
目的:探讨原发性肝癌经肝动脉化学治疗栓塞(transarterial chemoembolization,TACE)术后给予静脉三氧化二砷治疗对患者血清VEGF表达水平的影响。方法:连续性选择30例原发性肝癌TACE术后的患者,随机分为治疗组和对照组,每组15例病人,治疗组给予三氧化二砷注射液;对照组给予生理盐水治疗,比较两组TACE术前及术后第3,8,16天的血清VEGF变化。结果:TACE术后两组患者的血清VEGF值均动态升高,术后第3天和第8天,两组血清VEGF升高的水平基本相同,差异没有统计学意义(P>0.05)。治疗第16天时,治疗组的血清VEGF水平有明显下降的趋势,而对照组的血清VEGF值仍呈直线上升,两组差异具有统计学意义(P>0.01)。结论:原发性肝癌TACE术后给予三氧化二砷治疗,可能降低患者血清VEGF的表达水平。
Objective: To investigate the effect of transarterial chemoembolization (TACE) on the expression of VEGF in patients with primary hepatocellular carcinoma treated with intravenous arsenic trioxide. Methods: Thirty consecutive patients with primary hepatocellular carcinoma after TACE were randomly divided into treatment group and control group, with 15 patients in each group. The treatment group was treated with arsenic trioxide injection. The control group was treated with saline. TACE Preoperative and postoperative 3,8,16 days of serum VEGF changes. Results: Serum VEGF in both groups increased dynamically after TACE. The levels of serum VEGF in the two groups were basically the same on the 3rd and 8th day after operation. There was no significant difference between the two groups (P> 0.05). On the 16th day of treatment, the level of serum VEGF decreased obviously in the treatment group, while the serum VEGF value in the control group still increased linearly. The difference between the two groups was statistically significant (P> 0.01). Conclusion: The treatment of arsenic trioxide after TACE of primary hepatocellular carcinoma may reduce the expression of VEGF in serum.