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Pharmacodynamics是一个相沿已久的名词,在传统的概念中,其含意似与“药理学”并无区别(Goth A:Medical Pharmacology,1981)。自从Pharmacokinetics研究兴起之后,至今,两者已形成药理学的两大分支,因此对两词都需有新的概念。前者研究内容主要为药物效应及作用机制,包括量—效关系及构—效关系等,我们称之为“药效学”;至于后者则主要研究药物在体内随时间而发展的历程(Dorland’s Medical Dictionary,1981),具体地说,即体内药物浓度随时间的变化过程,国内文献多称之为“药物代谢动力学”,简称“药代动力学”,也有称药物动力学,现暂不强求一致。不言而喻,药效学与药代动力学密协相关,因此对两者的衔接进行理论的推导和综合的研究似为今后发展的趋向。为此,本期刊出下列涉及这方面的两文,希望就两者在概念的澄清上以及启发综合研究思考方面对读者有所裨益。
Pharmacodynamics is a longstanding term that, in the traditional notion, seems to differ from “pharmacology” (Goth A: Medical Pharmacology, 1981). Since the rise of the Pharmacokinetics research, so far, the two have formed two major branches of pharmacology, so both need a new concept. The former mainly focuses on the drug effects and mechanism of action, including the dose-effect relationship and the structure-activity relationship, which we call “Pharmacodynamics”. The latter mainly studies the course of drug development in vivo over time (Dorland’s Medical Dictionary, 1981). Specifically, the process of in vivo drug concentration changes with time. The domestic literature is often referred to as “pharmacokinetics”, referred to as “pharmacokinetics”, also known as pharmacokinetics, is now temporarily Consistency. It goes without saying that pharmacodynamics and pharmacokinetics are closely related, so the convergence of the two theoretical and synthetical research seems to be the future development trend. To this end, the current issue of the following two articles in this area, hoping to clarify the concept of both and to inspire comprehensive research and thinking of readers benefit.