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近年来,内分泌学方面的进展十分迅速。概括起来有以下几个方面:(一)由于环—磷酸腺苷(Cyclic AMP,cAMP)的发现,大大促进了关于激素作用原理的研究。目前认为旦白质、多肽和活性胺类激素作用于靶细胞时,首先与膜上的受体结合,激活腺苷酸环化酶,此酶在 Mg~(++)的作用下,使 ATP 转变为 cAMP;后者进一步激活旦白激酶,并通过旦白激酶的磷酸化作用,影响细胞内许多重要酶和功能旦自质(如核旦白、组旦白、细胞膜旦白质等)的活性,从而表现其特有的生物效应;这
In recent years, advances in endocrinology have been rapid. To sum up the following aspects: (a) due to the discovery of cyclic AMP (cAMP), greatly promoted the study on the principle of hormone action. Now that the white matter, peptides and active amine hormones act on the target cells, the first receptor with the membrane binding, activation of adenylate cyclase, the enzyme in Mg ~ (++) under the action of the ATP transition For the cAMP; the latter to further activate the protein kinase, and through the phosphorylation of protein kinase, affecting many of the key enzymes in the cell and functional denier (such as nuclear denier, denudin, cell membrane protein, etc.) activity, In order to show its unique biological effect;