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The pharmacokinetics of 16-dehydropregnenolone(16-DHP),a sterols compound isolated from Solanum lyratum Thunb.,was investigated in rats following a single intramuscular administration(40 mg/kg).The concentration of 16-DHP in rat plasma was determined by a high performance liquid chromatography(HPLC)method with UV detection.Levonorgestrel was used as the internal standard(IS).The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method.After a single intramuscular administration,the maximum plasma concentration(Cmax)was(289±25)ng/mL,time to reach Cmax(tmax)was(0.38±0.14)h,the elimination half-life(t1/2)was(2.5±1.1)h,the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration(AUC(0-t))was(544±73)ng·h/mL.The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.
The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., Was investigated in rats following a single intramuscular administration (40 mg / kg). The concentration of 16-DHP in rat plasma was determined by The high-performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a single intramuscular administration, the maximum plasma concentration (28 ± 25) ng / mL, time to reach Cmax (tmax) was (0.38 ± 0.14) h, the elimination half-life concentration-time curve from time zero to the time the last measurable concentration (AUC (0-t)) was (544 ± 73) ng · h / mL.The results indicated that 16-DHP was absorbed quickly and recently rapidly in rats after the intramuscular injection.