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妊娠期间,胎盘是一独特的器官,具有产生类固醇激素及非类固醇激素的功能。人胎盘产生的多肽激素主要有人绒毛膜促性腺激素(hCG)、人绒毛膜促生长激素(hCS)、人绒毛膜促甲状腺激素(hCT)、以及妊娠特异β_1糖蛋白(PSβ_1G)。它们均由合体滋养层细胞所产生,且可用放射免疫分析法测定之。本文描述这些激素的特征、作用及血清中的含量。人绒毛膜促性腺激素(hcG) hcG是最早得到阐明的糖蛋白激素。1927年Aschheim与Zondek报告,孕妇尿有促性腺的作用。60年代,此激素已被分离纯化,结构也已搞清。hCG的分子量为36,000-40,000道尔顿,糖约占分子重
During pregnancy, the placenta is a unique organ that produces steroid and non-steroid hormones. Human placenta produces peptide hormones mainly human chorionic gonadotropin (hCG), human chorionic somatotropin (hCS), human chorionic thyrotropin (hCT), and pregnancy-specific β 1 glycoprotein (PSβ_1G). They are produced by syncytiotrophoblasts and can be measured by radioimmunoassay. This article describes the features, effects, and serum levels of these hormones. Human chorionic gonadotropin (hcG) hcG is the earliest clarified glycoprotein hormone. Aschheim and Zondek reported in 1927 that the urine of pregnant women had a gonadal function. 60s, this hormone has been isolated and purified, the structure has also been identified. The hCG has a molecular weight of 36,000 to 40,000 daltons and the sugar accounts for the molecular weight