颅内动脉瘤(intracranial aneurysm,IA)是常见的脑血管病,人群患病率为3.2%[1],年破裂率约为1%[2]。虽然破裂率不高,但动脉瘤性蛛网膜下腔出血常导致灾难性后果,1个月内病死率高达35%[3]。尽管诊断方式和治疗措施不断改进,但IA生成、发展和最终破裂出血的发病机制仍不明确,使我们无法从根本上预防IA的发生。人类动脉瘤和动物动脉瘤模型研究表明,炎性反应介导的血管病理重构 Intracranial aneurysm (IA) is a common cerebrovascular disease with a prevalence of 3.2% [1] and an annual rate of rupture of about 1% [2]. Although rupture rate is not high, but aneurysmal subarachnoid hemorrhage often lead to catastrophic consequences, 1 month mortality rate as high as 35% [3]. Although the diagnostic methods and treatment measures continue to improve, the pathogenesis of IA formation, development and eventually rupture of the hemorrhage remains unclear, preventing us from fundamentally preventing the occurrence of IA. Human aneurysm and animal aneurysm model studies have shown that inflammatory response-mediated vascular pathology